abstract：PURPOSE:To use proton Magnetic Resonance Spectroscopy (MRS) to measure in vivo temporal lobe GABA and glutamate plus glutamine (GLX) concentrations in patients with temporal lobe epilepsy (TLE) attributable to unilateral hippocampal sclerosis (HS) before and following anterior temporal lobe resection (ATLR). METHODS:W...

journal_title：Epilepsy research

authors： Simister RJ,McLean MA,Barker GJ,Duncan JS

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:People with epilepsy may experience an altered pattern of mortality due to cancer. We determined cancer mortality in two distinct populations with epilepsy: (i) an institutionalised cohort with severe epilepsy (SEC) and (ii) another cohort with presumed milder epilepsy (MEC). METHODS:Mortality data from 197...

journal_title：Epilepsy research

authors： Singh G,Fletcher O,Bell GS,McLean AE,Sander JW

更新日期：2009-02-01 00:00:00

abstract：SUMMARY:Stereotactic radiofrequency amygdalohippocampectomy (AHE) has been reintroduced as an alternative treatment of mesial temporal lobe epilepsy. The aim of this study was to describe MRI changes after stereotactic AHE and to correlate the hippocampal and amygdalar volumes reduction with the clinical seizure outcom...

journal_title：Epilepsy research

authors： Malikova H,Vojtech Z,Liscak R,Prochazka T,Vymazal J,Vladyka V,Keller J,Kalina M

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To quantitatively analyze trajectory of movement in automatisms with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE). METHODS:Twenty markers were attached to chosen body parts of patients, and 10 videos of seizures were recorded. The obtained videos were converted into digital matrices. Motor tr...

journal_title：Epilepsy research

authors： Yang X,Chen L,Liu Y,Zeng D,Tang Y,Yan B,Lin X,Liu L,Xu H,Zhou D

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To explore the association between patient-reported-outcomes measurements and costs in adult outpatients with drug refractory epilepsy (DRE) in Spain. METHODS:Secondary analysis of a cross-sectional study to determine resources utilization and related costs of refractory epilepsy in Spain (LINCE study). Cons...

journal_title：Epilepsy research

authors： Peña P,Sancho J,Rufo M,Martínez S,Rejas J,LINCE Study Collaborative Group.

更新日期：2009-02-01 00:00:00

abstract：:Levetiracetam (LEV), a newer antiepileptic drug (AED) useful for several epilepsy syndromes, binds to SV2A. Identifying genetic variants that influence response to LEV may allow more tailored use of LEV. Obvious candidate genes are SV2A, SV2B and SV2C, which encode the only known binding site, synaptic vesicle protein...

journal_title：Epilepsy research

authors： Lynch JM,Tate SK,Kinirons P,Weale ME,Cavalleri GL,Depondt C,Murphy K,O'Rourke D,Doherty CP,Shianna KV,Wood NW,Sander JW,Delanty N,Goldstein DB,Sisodiya SM

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To discern more static and lesion based from more dynamic epilepsy-driven features of depression and personality in focal symptomatic epilepsy, change in personality and mood was examined as a function of focus lateralization and seizure outcome after epilepsy surgery. METHODS:Self-reported personality and dep...

journal_title：Epilepsy research

authors： Witt JA,Hollmann K,Helmstaedter C

更新日期：2008-12-01 00:00:00

abstract：:The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. In the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-D...

journal_title：Epilepsy research

authors： Trindade-Filho EM,de Castro-Neto EF,de A Carvalho R,Lima E,Scorza FA,Amado D,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Studies of adults who underwent temporal lobectomy for intractable temporal lobe epilepsy (TLE) demonstrated declining seizure free rates over time. Using seizure and social parameters, we followed patients who had temporal lobe surgery (TLS) in childhood to determine long-term outcomes. METHODS:We identified ...

journal_title：Epilepsy research

authors： Benifla M,Rutka JT,Otsubo H,Lamberti-Pasculli M,Elliott I,Sell E,RamachandranNair R,Ochi A,Weiss SK,Snead OC 3rd,Donner EJ

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Patients with epilepsy have excess morbidity and mortality due to ischemic cardiovascular disease. Many of these patients have elevated concentrations of plasma total homocysteine (Hcy), which is an acknowledged risk factor for cardiovascular disease, venous thromboembolic disease, foetal malformations and d...

journal_title：Epilepsy research

authors： Apeland T,Frøyland ES,Kristensen O,Strandjord RE,Mansoor MA

更新日期：2008-11-01 00:00:00

abstract：:Since magnetic resonance imaging (MRI) technique is constantly evolving with higher field strength scanners, the question arises whether images from different field strength scanners can be used interchangeably for scientific and clinical purposes. We address this issue in a study group of patients with temporal lobe ...

journal_title：Epilepsy research

authors： Scorzin JE,Kaaden S,Quesada CM,Müller CA,Fimmers R,Urbach H,Schramm J

更新日期：2008-11-01 00:00:00

abstract：:This study was carried out to evaluate Synthetic Aperture Magnetometry-kurtosis (SAM(g(2))), a spatially filtered source localization technique in magnetoencephalography (MEG), for identification of epileptogenic areas of focal cortical dysplasia (FCD). Three children with FCD were investigated to localize the ictal o...

journal_title：Epilepsy research

authors： Ishii R,Canuet L,Ochi A,Xiang J,Imai K,Chan D,Iwase M,Takeda M,Snead OC 3rd,Otsubo H

更新日期：2008-10-01 00:00:00

abstract：:Activation of group I metabotropic glutamate receptors (mGluRs) produces a long-lasting change in hippocampal excitability that persists in the absence of an agonist. Exposure to the group I mGluR agonist dihydroxyphenylglycine (DHPG) results in the induction of spontaneously occurring epileptiform activity in the CA3...

journal_title：Epilepsy research

authors： Karr L,Rutecki PA

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. METHODS:Mapping and radiofrequency ablation was performed via the venous system in two pigs. RESUL...

journal_title：Epilepsy research

authors： Henz BD,Friedman PA,Bruce CJ,Holmes DR Jr,Okumura Y,Johnson SB,Packer DL,Asirvatham SJ

更新日期：2008-08-01 00:00:00

abstract：:Ring chromosomes are rare chromosome disorders that arise usually de novo. Children with ring chromosome 6 have a wide range of intellectual functioning and congenital anomalies. We report an epileptic case of a 10-year-old boy to be mild psychomotor retardation and dysmorphic traits including microcephaly, brachyceph...

journal_title：Epilepsy research

authors： Kara N,Okten G,Guneş SO,Saglam Y,Tasdemir HA,Pinarli FA

更新日期：2008-08-01 00:00:00

abstract：:Paroxysmal kinesigenic dyskinesia (PKD) is a rare neurologic inherited disease with heterogeneity. Autosomal dominant (AD) is the common inherited mode. There have been two loci mapped to 16 chromosome for PKD. However, no gene responsible for it has been identified so far. We collected 6 pedigrees from Chinese mainla...

journal_title：Epilepsy research

authors： Zhou J,Li G,Chen C,Liu D,Xiao B

更新日期：2008-08-01 00:00:00

abstract：:Mutations in the LGI1 gene are linked to autosomal dominant lateral temporal epilepsy (ADTLE) in about half of the families tested, suggesting that ADLTE is genetically heterogeneous. Recently, the Lgi1 protein has been found associated with different protein complexes and two distinct molecular mechanisms possibly un...

journal_title：Epilepsy research

authors： Diani E,Di Bonaventura C,Mecarelli O,Gambardella A,Elia M,Bovo G,Bisulli F,Pinardi F,Binelli S,Egeo G,Castellotti B,Striano P,Striano S,Bianchi A,Ferlazzo E,Vianello V,Coppola G,Aguglia U,Tinuper P,Giallonardo AT,

更新日期：2008-07-01 00:00:00

abstract：:Epilepsy - the world's most common serious brain disorder - is defined by recurrent unprovoked seizures that result from complex interactions between distributed neural populations. We explore some macroscopic characteristics of emergent ictal networks by considering intracranial recordings from human subjects with in...

journal_title：Epilepsy research

authors： Kramer MA,Kolaczyk ED,Kirsch HE

更新日期：2008-05-01 00:00:00

abstract：:The ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment of intractable epilepsy. Recent studies suggest that the KD may be both anticonvulsant and antiepileptogenic. Epileptic seizures have been shown to stimulate the proliferation rate of neuronal progenitor cells in...

journal_title：Epilepsy research

authors： Kwon YS,Jeong SW,Kim DW,Choi ES,Son BK

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Intracranial EEG in patients with lesional lateral temporal lobe epilepsy is rarely reported. Therefore, the number of patients with seizures arising independently from ipsilateral mesial structures or contralateral hemisphere has not been clarified. We analyzed the intracranial EEG of cases with localized lesi...

journal_title：Epilepsy research

authors： Usui N,Mihara T,Baba K,Matsuda K,Tottori T,Umeoka S,Nakamura F,Terada K,Usui K,Inoue Y

更新日期：2008-01-01 00:00:00

abstract：:The subjects were 106 SMIDS with epilepsy. They were classified into four epileptic syndromes: (1) SE-MISF (34.0%), (2) SGE (25.5%), (3) SLRE (20.7%), and (4) epileptic discharge-free patients (EDFP) (19.8%). Clinical electroencephalographic studies elucidated the following result: (1) The seizure disappearance rate w...

journal_title：Epilepsy research

authors： Matsumoto A,Miyazaki S,Hayakawa C,Komori T,Nakamura M

更新日期：2007-12-01 00:00:00

abstract：:Clinical reports suggest that the elderly are hypersensitive to the neurological effects of domoic acid (DOM). In the present study we assessed DOM-induced seizures in young and aged rats, and seizure attenuation following low-dose DOM pretreatment (i.e. preconditioning). Seizure behaviours following saline or DOM adm...

journal_title：Epilepsy research

authors： Hesp BR,Clarkson AN,Sawant PM,Kerr DS

更新日期：2007-09-01 00:00:00

abstract：:An approach to the selection of appropriate antiepileptic drugs (AEDs) for inclusion in polytherapy is to take into account both the efficacy of a drug and also its mechanism of action and pharmacokinetic profile. The AED zonisamide is licensed in Europe and the USA for use as adjunctive therapy in adult patients with...

journal_title：Epilepsy research

authors： Baulac M,Leppik IE

更新日期：2007-07-01 00:00:00

abstract：:We hypothesized and found that the co-occurrence of migraine with aura (MA) with major depression (MD) or with suicide attempt (SA) increases the risk for developing unprovoked seizure more than these conditions alone. Number of conditions showed a linear relationship to seizure risk. This may reflect a new condition ...

journal_title：Epilepsy research

authors： Hesdorffer DC,Lúdvígsson P,Hauser WA,Olafsson E,Kjartansson O

更新日期：2007-07-01 00:00:00

abstract：:In order to assess the chloride channel gene CLCN2 as a candidate susceptibility gene for childhood absence epilepsy, parametric and non-parametric linkage analysis was performed in 65 nuclear pedigrees. This provided suggestive evidence for linkage with heterogeneity: NPL score=2.3, p<0.009; HLOD=1.5, alpha=0.44. Mut...

journal_title：Epilepsy research

authors： Everett K,Chioza B,Aicardi J,Aschauer H,Brouwer O,Callenbach P,Covanis A,Dooley J,Dulac O,Durner M,Eeg-Olofsson O,Feucht M,Friis M,Guerrini R,Heils A,Kjeldsen M,Nabbout R,Sander T,Wirrell E,McKeigue P,Robinson R,

更新日期：2007-07-01 00:00:00

abstract：:Treatment with cytochrome P450 enzyme-inducing antiepileptic drugs (P450-inducing AEDs) is known to interfere with folate metabolism. Low folate status is of special concern in women with epilepsy who might become pregnant. Therefore, folate status was assessed in women age 16-42 treated for epilepsy. Staple food is n...

journal_title：Epilepsy research

authors： Kampman MT

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:This study aimed to evaluate the carotid artery intima-media thickness (CA-IMT) in adult patients with epilepsy and its contribution to oxidative stress and vascular risk biomarkers. METHODS:This study included 225 adult epileptic and 60 control subjects. For all, CA-IMT, fasting lipid profile (TC, TG, HDL-c a...

journal_title：Epilepsy research

authors： Hamed SA,Hamed EA,Hamdy R,Nabeshima T

更新日期：2007-05-01 00:00:00

abstract：:Five oral formulations of valproic acid (VPA)/divalproex sodium are approved and commonly used in the US for treatment of epilepsy, mania/bipolar disorder and migraine prophylaxis. These formulations have unique pharmacokinetic and formulation characteristics and are designed to treat distinct patient populations. We ...

journal_title：Epilepsy research

authors： Dutta S,Reed RC

更新日期：2007-03-01 00:00:00

abstract：:Freeze-lesion-induced focal cortical dysplasia in rats closely resembles human microgyria, a neuronal migration disorder associated with drug-resistant epilepsy. Alterations in expression of N-methyl-D-aspartate receptors (NMDARs) containing NR2B subunits have been suggested to play a role in the hyperexcitability see...

journal_title：Epilepsy research

authors： Bandyopadhyay S,Hablitz JJ

更新日期：2006-12-01 00:00:00

abstract：:The parameters of pentylenetetrazol (PTZ)-induced seizures have been evaluated at various time intervals after lipopolysaccharide (LPS; Escherichia coli O111:B4, 100 microg/kg, i.p.) administration in mice. A proconvulsant effect occurred 4h after LPS injection with decreased seizure latency and enhanced seizure inten...

journal_title：Epilepsy research

authors： Akarsu ES,Ozdayi S,Algan E,Ulupinar F

更新日期：2006-10-01 00:00:00

abstract：:Plasma total homocysteine (p-tHcy), serum folate (s-F), serum vitamin B-12 (s-B12) and plasma pyridoxal-5'-phosphate (p-PLP) were measured in epileptic children before and after a 20-week period of sodium valproate (group A, n=32) and carbamazepine (group B, n=20) monotherapy. P-tHcy significantly increased in both gr...

journal_title：Epilepsy research

authors： Attilakos A,Papakonstantinou E,Schulpis K,Voudris K,Katsarou E,Mastroyianni S,Garoufi A

更新日期：2006-10-01 00:00:00

abstract：:The common features of all types of epilepsy are the synchronized and uncontrolled discharges of nerve cell assemblies. The reason for the pathologically synchronized discharges of the neuron is not exactly known yet. Recent reports claim that gap junctions have a critical role in neuronal synchronization. The present...

journal_title：Epilepsy research

authors： Bostanci MO,Bağirici F

更新日期：2006-10-01 00:00:00

abstract：:Spreading depression (SD), a self-propagating wave of reversible cellular depolarization, is thought to play an important role in brain pathophysiology. SD and seizures are closely related events but little is known about involvement of SD in chronic epileptogenesis. Here we show that cortical SD is the first and high...

journal_title：Epilepsy research

authors： Vinogradova LV,Vinogradov VY,Kuznetsova GD

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Polyunsaturated fatty acids have been reported to increase seizure threshold and to reduce seizure duration and severity in rats. OBJECTIVE:The purpose of the present study was to test the anticonvulsant effects of an essential fatty acid mixture containing linoleic and alpha-linolenic acids at a 4:1 ratio ...

journal_title：Epilepsy research

authors： Taha AY,Baghiu BM,Lui R,Nylen K,Ma DW,Burnham WM

更新日期：2006-09-01 00:00:00

abstract：:The efforts of the International League against Epilepsy (ILAE) to devise classifications of the epilepsies has greatly improved communication among epileptologists and influenced both basic and clinical research. Several classifications have been proposed since 1970; the most recent classification of epilepsy syndrom...

journal_title：Epilepsy research

authors： Engel J Jr

更新日期：2006-08-01 00:00:00

abstract：:Mutations in genes encoding ion channels in brain neurons have been identified in various epilepsy syndromes. In neuronal networks, "gain-of-function" of channels in excitatory neurotransmission could lead to hyper-excitation while "loss-of-function" in inhibitory transmission impairs neuronal inhibitory system, both ...

journal_title：Epilepsy research

authors： Hirose S

更新日期：2006-08-01 00:00:00

abstract：:Studying infantile spasms is challenging because there are so many aspects of variation that introduce potential bias. These might relate to the many underlying etiologies, and variations in clinical semiology and electroencephalographic features that relate more to age or timing of investigation than to the underlyin...

journal_title：Epilepsy research

authors： Lux AL,Osborne JP

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The aim of this study is to classify infantile cases with benign seizures into known epileptic syndromes, thereby facilitating discussion of clinical factors that could play an important role in diagnosis. SUBJECTS:Fifty-seven patients with afebrile seizures fulfilling all of the following criteria were enroll...

journal_title：Epilepsy research

authors： Tanabe T,Hara K,Kashiwagi M,Tamai H

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate by a prospective, self-controlled method, whether treatment with carbamazepine (CBZ) and sodium valproate (VPA) monotherapy may alter serum lipoprotein (a) [Lp(a)] concentrations in epileptic children. METHODS:Serum Lp(a) concentrations have been determined in 18 epilep...

journal_title：Epilepsy research

authors： Voudris KA,Attilakos A,Katsarou E,Drakatos A,Dimou S,Mastroyianni S,Skardoutsou A,Prassouli A,Garoufi A

更新日期：2006-08-01 00:00:00

abstract：:Cooling has been shown to terminate experimentally induced epileptiform activity in models of epilepsy without causing injury to the cooled brain, suggesting that cooling could represent an approach to seizure control in intractable focal epilepsies. Here we sought to determine the most effective way to apply cooling ...

journal_title：Epilepsy research

authors： Motamedi GK,Salazar P,Smith EL,Lesser RP,Webber WR,Ortinski PI,Vicini S,Rogawski MA

更新日期：2006-08-01 00:00:00